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Niall McLaren's avatar

This drug (sodium valproate) has been around for a long time and is extensively used in psychiatry. It was invented before epigenetic effects were known, long before gene technology was developed in modern form. Nobody at the time had a clue how it worked, and certainly not at the level described in this paper. On p568, they say: "We have proposed that demethylation might be a critical mechanism in metastasis and that DNA demethylating agents should be avoided when there is a concern for the development of metastasis (29,51). Therefore, the use of VPA and other HDAC inhibitors might be associated with similar problems."

All anticonvulsants have a huge range of side effects but if this one induced cancers or encouraged metastasis (spread), I think it would have become clear by this stage. So far, all they can say is "Be careful, these drugs have unpredictable side effects," which is hardly rocket science.

Drug manufacturers always try to find new uses of their stuff, they can make a tiny change and then get a new patent, which is much easier and cheaper than digging for gold.

Jason Aull's avatar

I did a search on refseek that said “ The economic underpinnings of a mental health diagnosis “. It was yet another search that came up dry for what I was looking for. For a long time I wondered why I was mentally ill and what I could do to no longer be mentally ill. I saw one time on television a court case that gave me a big clue. Apparently a woman was going into houses uninvited and doing cleaning. When she was brought to court for trespassing, she pleaded insanity. Apparently she was found guilty of trespassing for one reason. She demanded payment for what she was doing. This was the big piece in the puzzle. It started to become clear to me what the drugs and psych hospitalizations were really about. The problem was not really psychiatric, it was economic. All the DSM labels pretty much boiled down to one label-EDD(employment deficit disorder). The most disgusting of things can easily seem like the most amazing of things simply by some cash dished out because of some numbers on a price tag. Mood swings are not really the most desirable thing in the world but if they tend to make people millionaires with lucrative ideas, then all of a sudden people are looking for ways to become bipolar. What I am getting at is that there is a huge financial factor in what gets deemed mental “illness” and I’m not sure very many people are paying attention to it.

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